RNA Details
Disease Name
pulmonary hypertension
Tissue
lung
RNA Symbol
mir-145
RNA ID
RNA Type
miRNA
Alteration Pattern
dysregulation
Species
homo sapiens
Detection Methods
Immunohistochemistry; Laser-assisted microdissection and RNA extraction etc.
Target
MYOCARDIN; SMOOTH MUSCLE MYOSIN HEAVY CHAIN
Pathway
NA
PubMed ID
Title
Plexiform vasculopathy of severe pulmonary arterial hypertension and microRNA expression
Year
2012
Function
"Expression levels of miR-143/145 and its target proteins (e.G., Myocardin, smooth muscle myosin heavy chain) were found to be significantly higher in concentric obliterative lesions(CLs) than in plexiform lesions(PLs), whereas miR-126 and VEGF-A were significantly up-regulated in PLs when compared with CLs, indicating a more prominent angiogenic phenotype of PL. Down-regulation of miR-204 as well as an up-regulation of miR-21 in PLs in turn corresponds to enhanced cell proliferation. Morphologic changes of plexiform vasculopathy in the end-stage PAH lung are reflected by alterations at the miRNA level."